Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB6T7K)

Drug Name
Siramesine Drug Info
Synonyms
Siramesine; 147817-50-3; Lu-28-179; UNII-3IX8CWR24V; Lu 28-179; Siramesine(Lu 28-179); 3IX8CWR24V; CHEMBL61479; 1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine]; Siramesine [INN]; SCHEMBL2090079; QCR-66; C30H31FN2O; EX-A355; DTXSID90163810; XWAONOGAGZNUSF-UHFFFAOYSA-N; ZINC1533883; BCP08745; 4042AH; BDBM50035105; AKOS027251054; CS-1920; API0014138; NCGC00370727-06; HY-14221; 163630-80-6; 1'-(4-(1-(p-Fluorophenyl)indol-3-yl)butyl)spiro(phthalan-1,4'-piperidine)
Cross-matching ID
PubChem CID
9829526
CAS Number
CAS 147817-50-3
TTD Drug ID
DMB6T7K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-1A (ADRA1A) TTNGILX ADA1A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1B (ADRA1B) TTBRKXS ADA1B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1D (ADRA1D) TT34BHT ADA1D_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adrenergic receptor alpha-1A (ADRA1A) DTT ADRA1A 3.154 3.853 4.129 2.963
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-1A (ADRA1A) DTT ADRA1A 9.43E-01 -0.03 -0.25
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem. 1995 May 26;38(11):1998-2008.