Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBPNKT)

Drug Name
SC-44463 Drug Info
Synonyms
SC-44463; CHEMBL45483; n-[3-(n'-hydroxycarboxamido)-2-(2-methylpropyl)-propanoyl]-o-tyrosine-n-methylamide; 104408-38-0; Ihp-tyr-menh2; HTA; AC1L2U0O; SCHEMBL9284838; sc44463; BDBM50104969; DB07926; N-(2-Isobutyl-3-(N'-hydroxycarbonylamido)propanoyl)-O-methyltyrosinemethylamide; N*4*-Hydroxy-2-isobutyl-N*1*-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-succinamide; (2R)-N-hydroxy-N'-[(1S)-2-(4-methoxyphenyl)-1-(methylcarbamoyl)ethyl]-2-(2-methylpropyl)butanediamide; Butanediamide, N4-hydroxy-N1-(1-((4-methoxyphenyl)meth
Cross-matching ID
PubChem CID
128564
CAS Number
CAS 104408-38-0
TTD Drug ID
DMBPNKT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aggrecanase (ADAMTS5) TTXSU2Y ATS5_HUMAN Inhibitor [1]
Aggrecanase-1 (ADAMTS4) TTYG6BU ATS4_HUMAN Inhibitor [1]
Matrix metalloproteinase-1 (MMP-1) TTMX39J MMP1_HUMAN Inhibitor [2]
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [2]
Matrix metalloproteinase-3 (MMP-3) TTUZ2L5 MMP3_HUMAN Inhibitor [3]
Matrix metalloproteinase-7 (MMP-7) TTMTWOS MMP7_HUMAN Inhibitor [2]
Matrix metalloproteinase-8 (MMP-8) TTGA1IV MMP8_HUMAN Inhibitor [1]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aggrecanase (ADAMTS5) DTT ADAMTS5 5.527 6.073 5.885 6.287
Matrix metalloproteinase-3 (MMP-3) DTT MMP3 5.202 4.907 4.372 5.133
Matrix metalloproteinase-1 (MMP-1) DTT MMP1 2.263 0.263 2.433 5.403
Matrix metalloproteinase-7 (MMP-7) DTT MMP7 5.567 5.479 9.387 2.766
Matrix metalloproteinase-2 (MMP-2) DTT MMP2 5.766 9.299 8.247 8.608
Matrix metalloproteinase-8 (MMP-8) DTT MMP8 2.926 5.142 5.162 5.98
Matrix metalloproteinase-9 (MMP-9) DTT MMP9 6.725 7.358 6.384 6.921
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Matrix metalloproteinase-3 (MMP-3) DTT MMP3 4.17E-112 0.66 2.63
Matrix metalloproteinase-1 (MMP-1) DTT MMP1 2.68E-70 4.53 2.57
Matrix metalloproteinase-7 (MMP-7) DTT MMP7 6.83E-17 0.96 0.8
Matrix metalloproteinase-2 (MMP-2) DTT MMP2 8.17E-01 0.03 0.1
Matrix metalloproteinase-8 (MMP-8) DTT MMP8 1.19E-01 0.07 0.14
Matrix metalloproteinase-9 (MMP-9) DTT MMP9 3.53E-54 2.03 1.94
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50.
2 A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25.
3 Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics, Bioorg. Med. Chem. Lett. 7(18):2331-2336 (1997).