Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMC4IUQ)

Drug Name
5-(N,N-hexamethylene)-amiloride Drug Info
Synonyms
5-(N,N-Hexamethylene)amiloride; Hexamethyleneamiloride; 1428-95-1; Hexamethylene amiloride; HMA-5; HMA; C12H18ClN7O; 3-Amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide; N,N-HEXAMETHYLENEAMILORIDE; CHEBI:76400; 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)pyrazinecarboxamide; Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-; 5-HMA; Spectrum_001596
Indication
Disease Entry ICD 11 Status REF
Coronavirus infection 1D92 Preclinical [1]
Cross-matching ID
PubChem CID
1794
ChEBI ID
CHEBI:76400
CAS Number
CAS 1428-95-1
TTD Drug ID
DMC4IUQ
VARIDT Drug ID
DR00899

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Modulator (allosteric modulator) [2]
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Modulator (allosteric modulator) [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Gonadotropin-releasing hormone receptor (GNRHR) DTT GNRHR 4.372 3.926 1.433 0.926
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Coronavirus infection
ICD Disease Classification 1D92
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
2 Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor. Mol Pharmacol. 1998 May;53(5):916-25.
3 Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol. 2008 Jun;73(6):1808-15.