Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMC8J6F)

Drug Name

METHYLTHIOADENOSINE Drug Info

Synonyms

5'-Deoxy-5'-methylthioadenosine; 2457-80-9; Methylthioadenosine; 5'-S-methyl-5'-thioadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-DEOXY-5'-METHYLTHIOADENOSINE; (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol; Thiomethyladenosine; Vitamin L2; ADENOSINE, 5'-S-METHYL-5'-THIO-; 5'-S-Methylthioadenosine; MTA; S-methyl-5'-thioadenosine; Vitamin L(sub 2); UNII-634Z2VK3UQ; 5'-Deoxy(methylthio)adenosine; 5'-Deoxy-5'-Methylthioadenosine

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Terminated	[1]

Cross-matching ID

PubChem CID: 439176
ChEBI ID: CHEBI:17509
CAS Number: CAS 2457-80-9
TTD Drug ID: DMC8J6F
INTEDE Drug ID: DR2066

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[2]
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[2]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[2]
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[2]
S-methyl-5'-thioadenosine phosphorylase (MTAP)	TTDBX7N	MTAP_HUMAN	Inhibitor	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
S-adenosylhomocysteine nucleosidase (mtnN)	DE1DR6Y	MTNN_KLEPN	Investigative	[4]
S-methyl-5'-thioadenosine phosphorylase (MTAP)	DEXHBCR	MTAP_HUMAN	Investigative	[5]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adenosine A2b receptor (ADORA2B)	DTT	ADORA2B	4.853	6.925	4.536	5.409
Adenosine A2a receptor (ADORA2A)	DTT	ADORA2A	5.075	5.752	5.928	6.324
Adenosine A1 receptor (ADORA1)	DTT	ADORA1	4.698	5.291	5.298	4.797
Adenosine A3 receptor (ADORA3)	DTT	ADORA3	6.57	6.966	6.564	6.787
S-methyl-5'-thioadenosine phosphorylase (MTAP)	DME	MTAP	4.146	3.711	3.585	4.129

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

08 Nervous system disease

Disease Class

ICD-11: 8A40 Multiple sclerosis

The Studied Tissue

Plasmacytoid dendritic cells

The Studied Disease

Multiple sclerosis [ICD-11:8A40]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
S-methyl-5'-thioadenosine phosphorylase (MTAP)	DME	MTAP	2.81E-01	-6.84E-02	-2.78E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000987)
2	Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique aden... J Med Chem. 2004 Apr 22;47(9):2243-55.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7.
5	Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry. 2004 Jan 13;43(1):9-18.