Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCG1HE)

Drug Name
2-(1H-Imidazol-4-ylmethyl)-4-phenyl-thiazole Drug Info
Synonyms CHEMBL289060; 2-(1H-Imidazol-4-ylmethyl)-4-phenyl-thiazole; BDBM50014174
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
14742545
TTD Drug ID
DMCG1HE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 3A receptor (HTR3A) TTPC4TU 5HT3A_HUMAN Inhibitor [1]
5-HT 3B receptor (HTR3B) TTR6K75 5HT3B_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 3B receptor (HTR3B) DTT HTR3B 5.952 4.931 5.597 5.933
5-HT 3A receptor (HTR3A) DTT HTR3A 5.693 5.728 5.986 6.087
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 3B receptor (HTR3B) DTT HTR3B 3.82E-01 0.04 0.1
5-HT 3A receptor (HTR3A) DTT HTR3A 6.60E-01 1.08E-02 0.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists. J Med Chem. 1990 Jan;33(1):13-6.