Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCQARM)

• Drug Name: TTP889 Drug Info
• Synonyms: VP-14637; VP 14637; 235106-62-4; (E)-2,2'-((4-hydroxyphenyl)methylene)bis(4-((E)-(5-methyl-1H-tetrazol-1-ylimino)methyl)phenol); MDT-637; AC1O5AXS; CHEMBL3393516; SCHEMBL20741449; SCHEMBL16743389; CHEMBL3393661; (4E)-2-[(4-hydroxyphenyl)-[(3E)-3-[[(5-methyltetrazol-1-yl)amino]methylidene]-6-oxocyclohexa-1,4-dien-1-yl]methyl]-4-[[(5-methyltetrazol-1-yl)amino]methylidene]cyclohexa-2,5-dien-1-one; DB12195; ACM235106624; J-015135

Indication

Disease Entry	ICD 11	Status	REF
Blood forming organ disorder	JB64.1	Phase 2	[1]
Respiratory syncytial virus infection	1C80	Terminated	[2]

• Cross-matching ID:
  PubChem CID: 135484065
  CAS Number: CAS 235106-62-4
  TTD Drug ID: DMCQARM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor IX (F9)	TTFEZ5Q	FA9_HUMAN	Inhibitor	[1]
Measles virus Fusion glycoprotein (MeV F)	TTUPB12	FUS_MEASC	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Coagulation factor IX (F9)	DTT	F9	11.652	4.365	4.591	4.667

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Blood forming organ disorder
• ICD Disease Classification: JB64.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor IX (F9)	DTT	F9	5.69E-01	-0.13	-0.45

References

• [1] Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study. J Thromb Haemost. 2008 Mar;6(3):457-63.
• [2] Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17.