Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCUE25)

Drug Name

1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole Drug Info

Synonyms

183500-36-9; CHEMBL599601; 4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE; 1-(4-cyanobenzyl)-5-hydroxymethylimidazole; 1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole; SCHEMBL3630524; CTK4D8500; DTXSID40436662; ACFSBQWDVYWNRT-UHFFFAOYSA-N; ZINC45368822; BDBM50307240; ACM183500369; KB-238618; 1-(4-Cyanobenzyl)-5-Hydroxymethyl-imidazole; 1-(4-Cyanobenzyl)-5-(hydroxymethyl)imidazole; 1-(4-cyanobenzyl)-5-(hydroxymethyl) imidazole; 1-(4-cyanobenzyl)-5-(hydroxymethyl)-imidazole; 3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl alcohol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10198247
CAS Number: CAS 183500-36-9
TTD Drug ID: DMCUE25

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25.