Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCVJK9)

Drug Name
PMID19788238C66 Drug Info
Synonyms 1192216-03-7; GTPL8141; ZINC45245466; NSC752203; BDBM50299218; NSC-752203; KB-65160
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44478401
ChEBI ID
CHEMBL566515
TTD Drug ID
DMCVJK9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ephrin type-A receptor 1 (EPHA1) TTLFZVU EPHA1_HUMAN Inhibitor [1]
Ephrin type-A receptor 2 (EPHA2) TTRJB2G EPHA2_HUMAN Inhibitor [1]
Ephrin type-A receptor 3 (EPHA3) TTHS2LR EPHA3_HUMAN Inhibitor [1]
Ephrin type-A receptor 4 (EPHA4) TTG84D3 EPHA4_HUMAN Inhibitor [1]
Ephrin type-A receptor 5 (EPHA5) TTV9KOD EPHA5_HUMAN Inhibitor [1]
Ephrin type-A receptor 7 (EPHA7) TTAHTVG EPHA7_HUMAN Inhibitor [1]
Ephrin type-A receptor 8 (EPHA8) TTHZ2LW EPHA8_HUMAN Inhibitor [1]
Ephrin type-B receptor 1 (EPHB1) TT8MDAC EPHB1_HUMAN Inhibitor [1]
Ephrin type-B receptor 2 (EPHB2) TTKPV6O EPHB2_HUMAN Inhibitor [1]
Ephrin type-B receptor 3 (EPHB3) TT5LM7U EPHB3_HUMAN Inhibitor [1]
Ephrin type-B receptor 4 (EPHB4) TTI4ZX2 EPHB4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Ephrin type-B receptor 4 (EPHB4) DTT EPHB4 5.771 6.362 6.05 5.594
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Ephrin type-B receptor 4 (EPHB4) DTT EPHB4 4.05E-01 6.00E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46.