Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCWSJP)

Drug Name

SCH51866 Drug Info

Synonyms

SCH 51866; SCH-51866

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 1A (PDE1A)	TT73TEJ	PDE1A_HUMAN	Inhibitor	[2]
Phosphodiesterase 1B (PDE1B)	TT3ZS42	PDE1B_HUMAN	Inhibitor	[2]
Phosphodiesterase 1C (PDE1C)	TTW2HRK	PDE1C_HUMAN	Inhibitor	[2]
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[2]
Phosphodiesterase 7B (PDE7B)	TTWIEY9	PDE7B_HUMAN	Inhibitor	[3]
Phosphodiesterase 9 (PDE9)	TTZOEBC	PDE9A_HUMAN	Inhibitor	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 9 (PDE9)	DTT	PDE9A	1.807	8.131	3.263	2.7
Phosphodiesterase 5A (PDE5A)	DTT	PDE5A	3.632	3	3.632	4.271

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 9 (PDE9)	DTT	PDE9A	8.73E-03	0.07	0.36

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5270).
2	Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9.
3	Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83.
4	Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64.