General Information of Drug (ID: DMDFPIO)

Drug Name
PMID29130358-Compound-Figure13(4) Drug Info
Cross-matching ID
TTD Drug ID
DMDFPIO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [1]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Matrix metalloproteinase-2 (MMP-2) DTT MMP2 5.766 9.299 8.247 8.608
Matrix metalloproteinase-9 (MMP-9) DTT MMP9 6.725 7.358 6.384 6.921
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Matrix metalloproteinase-2 (MMP-2) DTT MMP2 1.23E-01 -0.29 -1.11
Matrix metalloproteinase-9 (MMP-9) DTT MMP9 1.12E-10 1.15 3.45
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.