Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDHFU9)

Drug Name

2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine Drug Info

Synonyms

CHEMBL45158; 159692-85-0; 2-(4-methylpiperazin-1-yl)-4-phenylpyrimidine; 2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine; SCHEMBL1275203; CTK0B0099; DTXSID80438281; QHOBPFOGFURKFZ-UHFFFAOYSA-N; BDBM50289600; 1-(4-Phenylpyrimidin-2-yl)-4-methylpiperazine; Pyrimidine, 2-(4-methyl-1-piperazinyl)-4-phenyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10332554
CAS Number: CAS 159692-85-0
TTD Drug ID: DMDHFU9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997).