Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDI98B)

• Drug Name: 2-(2-Methoxy-phenyl)-1-methyl-ethylamine Drug Info
• Synonyms: 1-(2-methoxyphenyl)propan-2-amine; 15402-84-3; N-Desmethylmethoxyphenamine; 2-Methoxyamphetamine; o-Methoxyamphetamine; NDMP; 2-(2-Methoxy-phenyl)-1-methyl-ethylamine; CHEMBL16451; Benzeneethanamine, 2-methoxy-alpha-methyl-; Benzeneethanamine,2-methoxy--methyl-; 1-(2-METHOXYPHENYL)-2-PROPYLAMINE; AC1L4MFB; AC1Q57OA; AC1Q45CZ; (d,l)-2-Methoxyamphetamine; Methoxyphenamine, N-desmethyl; SCHEMBL266563; o-Methoxy(phenylisopropyl)amine; AMBZ0414; AC1Q45D0; 2-Methoxy(phenylisopropyl)amine; o-Methoxy-a-methylphenethylamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 159755
  CAS Number: CAS 15402-84-3
  TTD Drug ID: DMDI98B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Inhibitor	[1]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129
5-HT 1D receptor (HTR1D)	DTT	HTR1D	3.307	1.263	2.585	5.833

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

References

• [1] 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9.