Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDL21W)

Drug Name

kisspeptin-10 Drug Info

Synonyms

RITKWYDZSSQNJI-INXYWQKQSA-N; Kisspeptin-10; KP-10; CHEMBL376756; 374675-21-5; Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2; KP10; KISS1; Kisspeptin 10 (human); GTPL1283; SCHEMBL15930211; BDBM26349; MolPort-023-276-491; Metastin (45-54) amide, human; BDBM50045513; AKOS024457174; Gene product (112-121) amide, human; Metastin (45-54) amide, human, > H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 25240297
CAS Number: CAS 374675-21-5
TTD Drug ID: DMDL21W

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 54 (KISS1R)	TT3KBZY	KISSR_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
G-protein coupled receptor 54 (KISS1R)	DTT	KISS1R	2.51E-03	0.74	0.91

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1283).
2	The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6.