Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDS4Q0)

Drug Name

3-(2-Chloro-1,1-dimethyl-2-phenyl-ethyl)-pyridine Drug Info

Synonyms

CHEMBL55746; 87372-77-8; 3-(1-Chloro-2-methyl-1-phenylpropan-2-yl)pyridine; 3-(2-Chloro-1,1-dimethyl-2-phenyl-ethyl)-pyridine; CTK3C4530; DTXSID30658230; BDBM50028163; Pyridine, 3-(2-chloro-1,1-dimethyl-2-phenylethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44299142
CAS Number: CAS 87372-77-8
TTD Drug ID: DMDS4Q0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9.