Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDYC4J)

Drug Name
PMID23489211C20 Drug Info
Synonyms PCM126; GTPL8124; BDBM50428059
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
71718651
ChEBI ID
CHEMBL2322989
TTD Drug ID
DMDYC4J

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ephrin type-A receptor 1 (EPHA1) TTLFZVU EPHA1_HUMAN Inhibitor [1]
Ephrin type-A receptor 2 (EPHA2) TTRJB2G EPHA2_HUMAN Inhibitor [1]
Ephrin type-A receptor 3 (EPHA3) TTHS2LR EPHA3_HUMAN Inhibitor [1]
Ephrin type-A receptor 4 (EPHA4) TTG84D3 EPHA4_HUMAN Inhibitor [1]
Ephrin type-A receptor 5 (EPHA5) TTV9KOD EPHA5_HUMAN Inhibitor [1]
Ephrin type-A receptor 6 (EPHA6) TTFAHWI EPHA6_HUMAN Inhibitor [1]
Ephrin type-A receptor 7 (EPHA7) TTAHTVG EPHA7_HUMAN Inhibitor [1]
Ephrin type-A receptor 8 (EPHA8) TTHZ2LW EPHA8_HUMAN Inhibitor [1]
Ephrin type-B receptor 1 (EPHB1) TT8MDAC EPHB1_HUMAN Inhibitor [1]
Ephrin type-B receptor 2 (EPHB2) TTKPV6O EPHB2_HUMAN Inhibitor [1]
Ephrin type-B receptor 3 (EPHB3) TT5LM7U EPHB3_HUMAN Inhibitor [1]
Ephrin type-B receptor 4 (EPHB4) TTI4ZX2 EPHB4_HUMAN Inhibitor [1]
Ephrin type-B receptor 6 (EPHB6) TTZEMUY EPHB6_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Ephrin type-B receptor 4 (EPHB4) DTT EPHB4 5.771 6.362 6.05 5.594
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Ephrin type-B receptor 4 (EPHB4) DTT EPHB4 4.05E-01 6.00E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47.