General Information of Drug (ID: DMECH9W)

Drug Name
(1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine Drug Info
Synonyms CHEMBL72703; AC1LTN5B; (1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine; cid_5051334; ZINC1773076; BDBM50116318; 2-phenyl-N-[(1S)-1-phenylethyl]quinazolin-4-amine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1564646
TTD Drug ID
DMECH9W

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine transporter (DAT) DTT SLC6A3 4 2.609 5.233 3.7
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine transporter (DAT) DTT SLC6A3 1.08E-03 -3.08 -1.99
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8.