Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEF603)

Drug Name

NSC-664171 Drug Info

Synonyms

NSC-664171; CHEMBL15778; 4(1H)-Quinolinone, 6-(1-pyrrolidinyl)-2-(3- methoxyphenyl)-; NSC664171; AC1Q6BII; AC1L8EB7; SCHEMBL7615804; ZINC5503291; BDBM50037450; NCI60_022072; 2-(3-methoxyphenyl)-6-pyrrolinylquinolin-4-one; 2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin-4-one; 2-(3-methoxyphenyl)-6-pyrrolidin-1-yl-1H-quinolin-4-one; 2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin-4-one (PQ-7)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 379514
TTD Drug ID: DMEF603

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[1]
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tubulin (TUB)	DTT	TUB	7.743	8.411	8.625	8.347

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tubulin (TUB)	DTT	NO-GeName	7.94E-02	0.35	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of a... J Med Chem. 1998 Mar 26;41(7):1155-62.