Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMENSL5)

Drug Name

Aminosalicylic Acid Drug Info

Synonyms

4-Aminosalicylic acid; 65-49-6; Aminosalicylic acid; P-AMINOSALICYLIC ACID; Rezipas; Aminopar; Pamisyl; Parasalindon; Ferrosan; Deapasil; Apacil; Parasal; Paser; Paramycin; Gabbropas; Parasalicil; Pasnodia; Osacyl; Aminox; Pasolac; Pasmed; Propasa; Pasalon; Entepas; Pasdium; Pasara; Pamacyl; Pasem; Pasa; 2-Hydroxy-4-aminobenzoic acid; PASK; APAS; Para-Pas; Sanipirol-4; Hellipidyl; Pascorbic; PAS-C; Benzoic acid, 4-amino-2-hydroxy-; PAS (acid); Aminosalicylic Acid Resin Complex; Aminosalicylate Sodium

Indication

Disease Entry	ICD 11	Status	REF
Crohn disease	DD70	Approved	[1]
Inflammatory bowel disease	DD72	Approved	[2]
Pulmonary and extrapulmonary tuberculosis	1B10.Z	Approved	[2]
Pulmonary tuberculosis	1B10.Z	Approved	[1]
Ulcerative colitis	DD71	Approved	[1]

Cross-matching ID

PubChem CID: 4649
ChEBI ID: CHEBI:27565
CAS Number: CAS 65-49-6
TTD Drug ID: DMENSL5
VARIDT Drug ID: DR01160
INTEDE Drug ID: DR1748

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrofolate reductase (DHFR)	TTYZVDJ	DYR_HUMAN	Modulator	[3]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Modulator	[3]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Modulator	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3)	DTKWJH3	S38A3_HUMAN	Approved	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
N-acetyltransferase 2 (NAT2)	DER7TA0	ARY2_HUMAN	Approved	[5]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023
Sodium-coupled neutral amino acid transporter 3 (SLC38A3)	DTP	SNAT3	8.347	5.545	3.722	4.524
N-acetyltransferase 2 (NAT2)	DME	NAT2	8.344	7.451	3.154	8.135

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Crohn disease

ICD Disease Classification

DD70

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 2 (COX-2)	DTT	PTGS2	2.03E-07	1.68	3.86
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	4.06E-03	-0.9	-2.26
Sodium-coupled neutral amino acid transporter 3 (SLC38A3)	DTP	SNAT3	1.97E-01	-1.70E-01	-3.65E-01
N-acetyltransferase 2 (NAT2)	DME	NAT2	1.27E-04	-1.50E+00	-3.00E+00

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Aminosalicylic acid FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66.
5	Importance of the evaluation of N-acetyltransferase enzyme activity prior to 5-aminosalicylic acid medication for ulcerative colitis. Inflamm Bowel Dis. 2016 Aug;22(8):1793-802.