General Information of Drug (ID: DMFEGYB)

Drug Name
NSC-65069 Drug Info
Synonyms
Phloroglucide; 491-45-2; 2,3',4,5',6-Biphenylpentol; NSC-65069; 2-(3,5-dihydroxyphenyl)benzene-1,3,5-triol; [1,1'-Biphenyl]-2,3',4,5',6-pentaol; NSC65069; UNII-U4GNW4D2BR; U4GNW4D2BR; Phloroglucide hydrate; CHEMBL1288340; [1,1'-Biphenyl]-2,3',4,5',6-pentol; (1,1'-Biphenyl)-2,3',4,5',6-pentol; Biphenyl-2,3',4,5',6-pentaol; 2,3',4,5',6-Pentahydroxybiphenyl; biphenyl-2,3',4,5',6-pentol; phloroglucid; NSC 65069; AC1Q7AZY; AC1L6M6T; Phloroglucide hydrate, 95%; NCIOpen2_003126; 2,4,5',6-Biphenylpentol; SCHEMBL278516
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
248349
CAS Number
CAS 491-45-2
TTD Drug ID
DMFEGYB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 1 (NQO1) TT8XK6L NQO1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Quinone reductase 1 (NQO1) DTT NQO1 5.453 7.493 8.082 7.086
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Quinone reductase 1 (NQO1) DTT NQO1 2.05E-04 0.89 2.67
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.