Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFGOW0)

Drug Name

NAAG Drug Info

Synonyms

N-acetylaspartylglutamate; spaglumic acid; isospaglumic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 3 (mGluR3)	TT8A9EF	GRM3_HUMAN	Agonist	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTWLACT	S17A5_HUMAN	Phase 4	[3]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Phase 4	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 3 (mGluR3)	DTT	GRM3	4.733	4.24	4.672	3.573
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTP	AST	7.618	7.419	7.95	7.127
Peptide transporter 1 (SLC15A1)	DTP	PEPT1	3.807	4.52	5.285	7.133

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 3 (mGluR3)	DTT	GRM3	6.89E-02	-0.39	-0.17
Metabotropic glutamate receptor 3 (mGluR3)	DTT	GRM3	4.60E-02	-0.05	-0.15
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTP	AST	2.33E-02	-1.08E-01	-3.68E-01
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTP	AST	6.95E-01	-5.94E-02	-3.11E-01
Peptide transporter 1 (SLC15A1)	DTP	PEPT1	2.28E-01	-5.07E-02	-2.49E-01
Peptide transporter 1 (SLC15A1)	DTP	PEPT1	9.68E-01	5.37E-02	5.24E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1405).
2	Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6.
3	Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8.
4	Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66.