Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFRASQ)

Drug Name

4-methyl-N-(naphthalen-1-yl)thiazol-2-amine Drug Info

Synonyms

CHEMBL383736; AC1LEV1N; Maybridge1_006094; 4-methyl-N-(naphthalen-1-yl)thiazol-2-amine; SCHEMBL14433296; HMS558M22; CCG-716; MolPort-000-432-043; ZINC5730833; BDBM50183094; AKOS002285219; MCULE-5807523116; ST50046832; (4-methyl(1,3-thiazol-2-yl))naphthylamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 692856
TTD Drug ID: DMFRASQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 4 (CCR4)	TT7HQD0	CCR4_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-C chemokine receptor type 4 (CCR4)	DTT	CCR4	5.07	5.952	5.771	5.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-C chemokine receptor type 4 (CCR4)	DTT	CCR4	2.33E-02	3.98E-03	0.03

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3.