Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG4ITB)

Drug Name

2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide Drug Info

Synonyms

2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide; CHEMBL417648; NSC36432; AC1L5TZB; AC1Q6VD0; N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide; aromatic sulfonamide compound 9; SCHEMBL16057183; BDBM16644; acetamide, n-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoro-; MolPort-001-023-586; KYCGMLPXHVMDAN-UHFFFAOYSA-N; ZINC993502; HMS1580F07; STK413007; NSC-36432; 4-Trifluoroacetamido-benzenesulfonamide; AKOS001720753; MCULE-7425586358; SDCCGMLS-0064722.P001; ST45139606; EU-0050996; AB00079123-01; SR-01000408197; AK-968/10112031

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 235259
CAS Number: CAS 6275-99-6
TTD Drug ID: DMG4ITB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XII (CA-XII)	DTT	CA12	6.015	9.06	10.222	5.773
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase XII (CA-XII)	DTT	CA12	3.29E-21	1.27	1.02
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.