Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG5QJB)

Drug Name
(+)-MCPG Drug Info
Synonyms
(S)-Mcpg; (S)-MCPG; (+)-alpha-Methyl-4-carboxyphenylglycine; (S)-(ALPHA)-METHYL-4-CARBOXYPHENYLGLYCINE; 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid; 4-(1-AMINO-1-CARBOXY-ETHYL)-BENZOIC ACID; UNII-61F6J48NHR; alpha-Mcpg; 61F6J48NHR; CHEMBL257626; CHEBI:43876; alpha-Methyl-cpgly; (S)-a-methyl-4-carboxyphenylglycine; (S)- -Methyl-4-carboxyphenylglycine; (S)-4-(1-amino-1-carboxyethyl)benzoic acid; (S)-(+)-alpha-methyl-4-carboxyphenylglycine; MCG; (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic; alpha-Mcpg; alpha-methyl-4-carboxyphenylglycine; alpha-methyl-cpgly; 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
446355
ChEBI ID
CHEBI:43876
CAS Number
CAS 150145-89-4
TTD Drug ID
DMG5QJB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metabotropic glutamate receptor 1 (mGluR1) TTVBPDM GRM1_HUMAN Antagonist [2]
Metabotropic glutamate receptor 2 (mGluR2) TTXJ47W GRM2_HUMAN Antagonist [3]
Metabotropic glutamate receptor 3 (mGluR3) TT8A9EF GRM3_HUMAN Antagonist [4]
Metabotropic glutamate receptor 5 (mGluR5) TTHS256 GRM5_HUMAN Antagonist [5]
Metabotropic glutamate receptor 7 (mGluR7) TT0I76D GRM7_HUMAN Antagonist [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Metabotropic glutamate receptor 2 (mGluR2) DTT GRM2 3.621 3.472 3.053 4.225
Metabotropic glutamate receptor 1 (mGluR1) DTT GRM1 3.888 3.848 3.711 3.678
Metabotropic glutamate receptor 5 (mGluR5) DTT GRM5 3.621 1.888 3.567 4.318
Metabotropic glutamate receptor 3 (mGluR3) DTT GRM3 4.733 4.24 4.672 3.573
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Metabotropic glutamate receptor 5 (mGluR5) DTT GRM5 9.81E-07 -0.26 -0.54
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1373).
2 [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93.
3 Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504.
4 [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29.
5 Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.
6 Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.