Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG78U2)

Drug Name

2-Hydrazinocarbonyl-benzenesulfonamide Drug Info

Synonyms

102169-52-8; 2-(hydrazinecarbonyl)benzenesulfonamide; 2-(hydrazinocarbonyl)benzenesulfonamide; 2-Hydrazinocarbonyl-benzenesulfonamide; 2-(hydrazinecarbonyl)benzene-1-sulfonamide; Benzoic acid,2-(aminosulfonyl)-, hydrazide; hydrazide deriv. 6; AC1M8OJR; ACMC-1BW2D; AC1Q54UM; Oprea1_607731; CHEMBL361191; CTK4A0755; BDBM12153; DTXSID30368807; HMS1788K01; ZX-AN012798; ZINC3372954; ALBB-014056; 7604AC; STL301522; AKOS000116142; FCH1317207; MCULE-6758898279; 2-(hydrazinylcarbonyl)benzenesulfonamide; BBV-40193034; Benzoic acid, 2-(aminosul

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2490720
CAS Number: CAS 102169-52-8
TTD Drug ID: DMG78U2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5.