General Information of Drug (ID: DMG8KRN)

Drug Name
4,5-Dihydroxy-10H-anthracen-9-one Drug Info
Synonyms CHEMBL124951; Isoanthralin; 4,5-Dihydroxy-10H-anthracen-9-one; 1,8-dihydroxy-10-anthrone; ZINC13606497; BDBM50060858
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
13379482
TTD Drug ID
DMG8KRN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.966 5.133 5.358 6.128
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.15E-01 -0.06 -0.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80.