Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGI9SM)

Drug Name

Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester Drug Info

Synonyms

MFMOme; Methyl, 2-fluoromethyl-2,5-diamino-3-pentenoate; Mdl-72403; methyl (E)-2,5-diamino-2-(fluoromethyl)pent-3-enoate; 2-(Fluoromethyl)dehydroornithine methyl ester; 107742-04-1; AC1O5Q3S; SCHEMBL6361254; 2,5-Diamino-2-(fluoromethyl)-3-pentenoic acid methyl ester; 96681-91-3; .alpha.-monofluoromethyldehydroornithine methyl ester; 3-Pentenoic acid, 2,5-diamino-2-(fluoromethyl)-, methyl ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6438668
CAS Number: CAS 96681-91-3
TTD Drug ID: DMGI9SM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Ornithine decarboxylase (ODC1)	DTT	ODC1	9.956	8.598	9.482	8.752

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Ornithine decarboxylase (ODC1)	DTT	ODC1	5.20E-35	1.58	2.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.