Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGMXQC)

Drug Name

STEPHOLIDINE Drug Info

Synonyms

l-Stepholidine; 16562-13-3; (-)-Stepholidine; stepholidine; (S)-3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,10-diol; S-Stepholidine; UNII-0UPX3E69W8; 0UPX3E69W8; Q-100198; (13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol; 3,9-Dimethoxy-13a-alpha-berbine-2,10-diol; l-2,10-Dihydroxy-3,9-dimethyloxytetrahydropseudoberberine; L-(S)-Stepholidine; l-SPD; AC1OCEV4; 13a-alpha-BERBINE-2,10-DIOL, 3,9-DIMETHOXY-; GTPL8370; DIB014; CHEMBL487387; SCHEMBL10001966

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6917970
CAS Number: CAS 16562-13-3
TTD Drug ID: DMGMXQC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D1 receptor (D1R)	TTZFYLI	DRD1_HUMAN	Inhibitor	[2]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Inhibitor	[2]
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Inhibitor	[2]
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Inhibitor	[2]
Dopamine D5 receptor (D5R)	TTS2PH3	DRD5_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D1 receptor (D1R)	DTT	DRD1	5.04	4.626	2.459	1.322
Dopamine D5 receptor (D5R)	DTT	DRD5	7.097	6.724	6.896	7.369
Dopamine D2 receptor (D2R)	DTT	DRD2	5.345	5.634	5.789	5.901
Dopamine D4 receptor (D4R)	DTT	DRD4	2.138	1.766	1.322	1
Dopamine D3 receptor (D3R)	DTT	DRD3	1.379	2.446	1.233	1.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D1 receptor (D1R)	DTT	DRD1	8.99E-01	-0.06	-0.3
Dopamine D2 receptor (D2R)	DTT	DRD2	2.20E-03	-0.51	-1.35
Dopamine D4 receptor (D4R)	DTT	DRD4	1.90E-01	0.19	0.76
Dopamine D3 receptor (D3R)	DTT	DRD3	2.84E-03	0.13	2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8370).
2	Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities Bioorg Med Chem. 2009 Oct 1;17(19):6898-907.