Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH3R21)

Drug Name

N-(3-acetamidophenyl)-3-chlorobenzamide Drug Info

Synonyms

N-(3-acetamidophenyl)-3-chlorobenzamide; CHEMBL1080810; N-[3-(acetylamino)phenyl]-3-chlorobenzamide; 3-chloro-N-(3-acetamidophenyl)benzamide; AC1LDLQ1; AC1Q1KO6; Cambridge id 5554516; Oprea1_130541; Oprea1_356143; MLS002699912; CHEBI:93070; ZINC29723; MolPort-001-508-240; STK036460; BDBM50312136; AKOS001296542; MCULE-8869105852; 312632-92-1; ST042764; SMR001530668; EU-0002463; AB00088853-01; SR-01000407944; SR-01000407944-1; N-{3-[(3-chlorophenyl)carbonylamino]phenyl}acetamide; Z28281866

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 669190
ChEBI ID: CHEBI:93070
TTD Drug ID: DMH3R21

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	3.621	1.888	3.567	4.318

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6.