Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH6OPI)

Drug Name

4-Bromo-6-nitro-2-piperazin-1-yl-quinoline Drug Info

Synonyms

4-Bromo-6-nitroquipazine; 143954-73-8; CHEMBL167825; 4-Bromo-6-nitro-2-piperazin-1-yl-quinoline; Quinoline, 4-bromo-6-nitro-2-(1-piperazinyl)-; ACMC-20n3fo; SCHEMBL6364738; AC1L318Y; CTK0I3188; DTXSID50162581; NRCNLRMWSMFETI-UHFFFAOYSA-N; BDBM50110574

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 132590
CAS Number: CAS 143954-73-8
TTD Drug ID: DMH6OPI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5.