Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH908V)

Drug Name

5-Bromomethyl-oxazolidin-(2Z)-ylideneamine Drug Info

Synonyms

5-Bromomethyl-4,5-dihydro-oxazol-2-ylamine; CHEMBL447832; 52886-60-9; 5-(bromomethyl)-4,5-dihydro-1,3-oxazol-2-amine; AC1MJII5; 5-Bromomethyl-oxazolidin-(2Z)-ylideneamine; SCHEMBL11817450; MolPort-001-940-341; 5-(Bromomethyl)oxazolidine-2-imine; SBB010634; BDBM50138186; AKOS016344418; AKOS000301813; BAS 00615750; 5-(bromomethyl)-1,3-oxazoline-2-ylamine; BB 0261596

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3112983
TTD Drug ID: DMH908V

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6.