Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH9RTV)

Drug Name
Omigapil Drug Info
Synonyms Omigapil); CGP-3466; CGP-3499B; Neuroprotectant, Novartis; Neuroprotectant, Santhera; Nootropic agent, Novartis; Nootropicagent, Santhera; SNT-317; TCH-346; TCH-346B
Indication
Disease Entry ICD 11 Status REF
Lateral sclerosis 8B61 Phase 2 [1]
Muscular dystrophy 8C70 Phase 1 [2]
Cross-matching ID
PubChem CID
6419718
ChEBI ID
CHEBI:41778
CAS Number
CAS 181296-84-4
TTD Drug ID
DMH9RTV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) TTUGSWA G3P_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) DTT GAPDH 12.082 12.019 12.258 11.809
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 08 Disease of the nervous system
Disease Class ICD-11: 8A00 Parkinsonism
The Studied Tissue Cervical spinal cord
The Studied Disease Lateral sclerosis [ICD-11:8A00.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) DTT GAPDH 5.24E-01 -0.21 -0.24
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00649961) Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3887-9.