Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHETPI)

Drug Name
ISIS-FXI Drug Info
Indication
Disease Entry ICD 11 Status REF
Coagulation defect 3B10.0 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMHETPI

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Factor XI messenger RNA (F11 mRNA) TTDM4ZU FA11_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Factor XI messenger RNA (F11 mRNA) DTT F11 8.057 5.368 5.527 5.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Coagulation defect
ICD Disease Classification 3B10.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Factor XI messenger RNA (F11 mRNA) DTT F11 8.24E-01 -3.39E-03 -0.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01713361) Active Comparator-Controlled Study to Assess Safety and Efficacy of ISIS-FXIRx in Total Knee Arthroplasty. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).