Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHETZN)

Drug Name

F-18 exendin-4 derivative PET tracers Drug Info

Synonyms

[18F]FB12-Ex4; [18F]FB40-Ex4; F-18 exendin-4 derivative PET tracers (diabetes); F-18 exendin-4 derivative PET tracers (diabetes), Kyoto University/Arkray

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMHETZN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon-like peptide 1 receptor (GLP1R)	TTVIMDE	GLP1R_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	2	2.848	3.472	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	1.25E-01	0.17	1.26

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).