Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHIG9K)

• Drug Name: Beta-D-Mannose Drug Info
• Synonyms: beta-D-Mannopyranose; beta-D-Mannose; beta-Mannose; 7322-31-8; UNII-CUO87O37MT; (2R,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; CUO87O37MT; CHEBI:28563; beta-1,4-Mannan; Epitope ID:137485; (1-> 2)-beta-D-mannan; 4)-beta-D-mannan; AC1L97TQ; SCHEMBL396651; 2)-beta-D-mannopyranan; CHEBI:80962; CHEBI:59573; CHEBI:27857; [2)-beta-D-Manp-(1-> WQZGKKKJIJFFOK-RWOPYEJCSA-N; ZINC3830679; GUP; NE16895; C02209; WURCS=2.0/1,1,0/[a1122h-1b_1-5]/1/; (2RS,3S,4S,5S,6R)-6-(Hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 439680
  ChEBI ID: CHEBI:28563
  CAS Number: CAS 7322-31-8
  TTD Drug ID: DMHIG9K

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[1]
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[1]
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[1]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]
Rhodopsin (RHO)	TTH0KSX	OPSD_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XIV (CA-XIV)	DTT	CA14	6.263	6.538	6.531	6.293
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.