Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHKUBG)

Drug Name

vesamicol Drug Info

Synonyms

vesamicol; VESAMICOL HYDROCHLORIDE; 22232-64-0; CHEMBL20943; MLS000554350; 2-(4-Phenyl-piperidin-1-yl)-cyclohexanol; Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-; 2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol; AH-5183; 2-(4-Phenyl-1-piperidinyl)cyclohexanol; SMR000146667; 2-(4-Phenylpiperidino)cyclohexanol; 23965-53-9; V-100; Spectrum_000292; Opera_ID_322; AC1Q7BAI; AC1L1KUQ; Prestwick1_000920; Spectrum3_001861; Prestwick0_000920; Prestwick2_000920; Oprea1_778558; Lopac0_001228; Oprea1_695768; KBioSS_000772; BSPBio_003302; MLS001201728

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5662
ChEBI ID: CHEBI:103974
CAS Number: CAS 22232-64-0
TTD Drug ID: DMHKUBG
VARIDT Drug ID: DR00964

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vesicular acetylcholine transporter (SLC18A3)	TTV8KWS	VACHT_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vesicular acetylcholine transporter (SLC18A3)	DTT	SLC18A3	2.53E-01	-0.15	-0.19

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4759).
2	Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor. Biochem Pharmacol. 1995 Mar 15;49(6):791-7.