Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHN2LT)

Drug Name

CP-94,253 Drug Info

Synonyms

CP-94253; CP-94,253; Tocris-1317; NCGC00025108-01; AC1N1FU8; SCHEMBL9695044; GTPL3221; CHEMBL1570196; CHEBI:92591; ZINC1894220; BCP28082; AKOS022184337; CP94253; CP94253NIEaNI/CP94253NIEaNI; AJ-32224; LS-139500; L003950; BRD-K33860217-003-01-6; 4-{5-propoxypyrrolo[3,2-b]pyridin-3-yl}-1,2,3,6-tetrahydropyridine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4029677
ChEBI ID: CHEBI:92591
CAS Number: CAS 131084-35-0
TTD Drug ID: DMHN2LT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1B receptor (HTR1B)	TTK8CXU	5HT1B_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1B receptor (HTR1B)	DTT	HTR1B	5.781	3.121	6.267	4.986

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1B receptor (HTR1B)	DTT	HTR1B	3.68E-03	0.16	0.92

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3221).
2	Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav. 2002 Apr;71(4):581-7.