Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHP9BL)

Drug Name

Etelcalcetide Drug Info

Synonyms

Velcalcetide; Parsabiv; UNII-60ME133FJB; 1262780-97-1; 60ME133FJB; etelcalcetide HCl; Etelcalcetide [USAN:INN]; Etelcalcetide (USAN/INN); Etelcalcetide Hydrochloride(AMG-416)

Indication

Disease Entry	ICD 11	Status	REF
Secondary hyperparathyroidism	5A51.1	Approved	[1]
Myelodysplastic syndrome	2A37	Phase 3	[2]

Cross-matching ID

PubChem CID: 71511839
ChEBI ID: CHEBI:134700
CAS Number: CAS 1262780-97-1
TTD Drug ID: DMHP9BL
ACDINA Drug ID: D01061

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Extracellular calcium-sensing receptor (CASR)	TTBUYHA	CASR_HUMAN	Modulator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Extracellular calcium-sensing receptor (CASR)	DTT	CASR	4.966	4.892	5.342	5.37

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Secondary hyperparathyroidism

ICD Disease Classification

5A51.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Extracellular calcium-sensing receptor (CASR)	DTT	CASR	4.50E-02	0.23	4.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031284)
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.