Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHQP84)

Drug Name

BW B218C Drug Info

Synonyms

BW B218C; BW-B218C; ZLIVOFMPDUIULQ-VAWYXSNFSA-N; 134470-36-3; AC1O5RJN; SCHEMBL6008832; N-(1-Methyl-3-(3-phenoxyphenyl)prop-2-enyl)acetohydroxamic acid; N-hydroxy-N-[(E)-4-(3-phenoxyphenyl)but-3-en-2-yl]acetamide; Acetamide, N-hydroxy-N-(1-methyl-3-(3-phenoxyphenyl)-2-propenyl)-; (+)-(E)-N-[1-methyl-3-(3-phenoxyphenyl)prop-2-enyl]acetohydroxamic acid; N-[(E)-3-(3-Phenoxyphenyl)-1-methyl-2-propenyl]acetohydroxamic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6439376
CAS Number: CAS 134470-36-3
TTD Drug ID: DMHQP84

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99.