Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHXJ68)

Drug Name
WVE-210201 Drug Info
Indication
Disease Entry ICD 11 Status REF
Duchenne dystrophy 8C70 Phase 2/3 [1]
Cross-matching ID
TTD Drug ID
DMHXJ68

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dystrophin (DMD) TT48MP6 DMD_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dystrophin (DMD) DTT DMD 6.356 5.446 5.459 5.326
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Duchenne dystrophy
ICD Disease Classification 8C70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dystrophin (DMD) DTT DMD 1.15E-07 -1.07 -2.94
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03907072) Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy (DYSTANCE 51). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)