Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHZ5SB)

Drug Name
8-Methoxy-quinolin-2-ylamine Drug Info
Synonyms
2-Quinolinamine, 8-methoxy-; 8-Methoxyquinolin-2-amine; 104090-86-0; CHEMBL77072; 8-Methoxy-quinolin-2-ylamine; ACMC-20m6vk; SCHEMBL1655715; CTK0G6598; DTXSID90624077; MolPort-020-915-686; PMXFKGCLUAFLMH-UHFFFAOYSA-N; 2-AMINO-8-METHOXYQUINOLINE; ZINC26399714; BDBM50025466; AKOS013465271
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
22266820
CAS Number
CAS 104090-86-0
TTD Drug ID
DMHZ5SB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Inhibitor [1]
5-HT 1D receptor (HTR1D) TT6MSOK 5HT1D_HUMAN Inhibitor [1]
Melanin-concentrating hormone receptor 1 (MCHR1) TTX4RTB MCHR1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Melanin-concentrating hormone receptor 1 (MCHR1) DTT MCHR1 4.392 4.823 5.433 5.725
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
5-HT 1D receptor (HTR1D) DTT HTR1D 3.307 1.263 2.585 5.833
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 2.18E-01 -0.11 -0.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80.
2 Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.