Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIB3J2)

Drug Name
Hexahydro-pyrrolizin-(3E)-ylideneamine Drug Info
Synonyms Hexahydro-pyrrolizin-(3E)-ylideneamine; CHEMBL185535; 765304-80-1; 3h-pyrrolizin-3-imine,hexahydro-; BDBM50150910
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44393480
TTD Drug ID
DMIB3J2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase brain (NOS1) TTZUFI5 NOS1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nitric-oxide synthase brain (NOS1) DTT NOS1 6.085 5.844 5.849 5.806
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nitric-oxide synthase brain (NOS1) DTT NOS1 5.20E-01 0.02 0.07
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44.