Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIH38V)

Drug Name

ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID Drug Info

Synonyms

alpha-hydroxyfarnesylphosphonic acid; HFPA; MONZTFSZTWQCKH-IJFRVEDASA-N; 140633-12-1; 148796-53-6; alpha-Hydroxyfarnesylphosphonic aicd; alpha-hydroxy Farnesyl Phosphonic Acid; AC1NS45W; C15H27O4P; MolPort-003-941-743; HMS3649I13; 1609AH; .alpha.-hydroxy Farnesyl Phosphonic Acid; RT-011376; C-28812; SR-01000946574; J-008515; SR-01000946574-1; L-704272; 1-Hydroxy-3,7,11-trimethyl-2E,6E,10-dodecatriene-1-phosphonic acid; [1-Hydroxy-(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5353399
CAS Number: CAS 148796-53-6
TTD Drug ID: DMIH38V

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CAAX farnesyltransferase beta (FNTB)	TT7WZIJ	FNTB_HUMAN	Inhibitor	[1]
Farnesyl protein transferase (Ftase)	TTXQKM3	FNTA_HUMAN; FNTB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Farnesyl protein transferase (Ftase)	DTT	FNTB	7.914	8.13	7.856	8.107

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Farnesyl protein transferase (Ftase)	DTT	FNTB; FNTA	5.43E-01	-0.1	-0.4

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.