Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIHFQY)

• Drug Name: HOMOAROMOLINE Drug Info
• Synonyms: Homoaromoline; (+)-Homoaromoline; Thalrugosamine; 6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol; 17132-74-0; NSC 251213; CHEMBL509855; NSC-251213; Oxyacanthan-7-ol, 6,6',12'-trimethoxy-2,2'-dimethyl-; (+)-Thalrugosamine; Homothalicrine; Limacusine (R,S); ( )-Thalrugosamine; Homothalicrine (7CI); SCHEMBL2991819; AC1Q58F3; AC1L410X; DTXSID90169059; NSC251213; BDBM50241641; LS-75888; Oxyacanthan-7-ol,6',12'-trimethoxy-2,2'-dimethyl-; Oxyacanthan-7-ol, 6,6',12'-trimethoxy-2,2'-dimethyl- (9CI)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 99620
  CAS Number: CAS 17132-74-0
  TTD Drug ID: DMIHFQY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99

References

• [1] Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.