Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIJCH1)

Drug Name
GR-218231 Drug Info
Synonyms
GR 218231; GR218231; CHEMBL131556; 175442-95-2; (+)-(2R)-1,2,3,4-Tetrahydro-6-[[(4-methoxyphenyl)sulfonyl]methyl]-N,N-dipropyl-2-naphthalenamine; (2R)-6-[(4-methoxyphenyl)sulfonylmethyl]-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine; AC1NSM1X; GR 218,231; GTPL70; SCHEMBL626977; DTXSID70415546; ZINC3824084; PDSP2_001398; PDSP1_001414; BDBM50214486; (3R)-N,N-Dipropyl-7-(4-methoxyphenylsulfonylmethyl)tetralin-3beta-amine
Cross-matching ID
PubChem CID
24840389
TTD Drug ID
DMIJCH1

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D3 receptor (D3R) TT4C8EA DRD3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine D3 receptor (D3R) DTT DRD3 1.379 2.446 1.233 1.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D3 receptor (D3R) DTT DRD3 5.74E-02 0.05 0.34
Dopamine D3 receptor (D3R) DTT DRD3 2.15E-01 -0.05 -0.46
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of t... Bioorg Med Chem. 2009 Jan 15;17(2):758-66.