Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIPY3W)

Drug Name

(E)-5-octadecen-7,9-diynoic acid Drug Info

Synonyms

5E-Octadecene-7,9-diynoic acid; CHEMBL489540; LMFA01030737; GTPL2963; ACon1_001719; BDBM50292398; compound 6a [Patil et al, 1989]; (5E)-octadec-5-en-7,9-diynoic acid; NCGC00180210-01; compound 6a (Patil et al., 1989)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9543636
TTD Drug ID: DMIPY3W

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
HMG-CoA reductase (HMGCR)	DTT	HMGCR	6.357	6.256	5.17	6.85

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
HMG-CoA reductase (HMGCR)	DTT	HMGCR	1.01E-05	0.65	1.53

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989).