General Information of Drug (ID: DMIS7NT)

Drug Name
PMID16242323C18b Drug Info
Synonyms GTPL6728
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
73755236
TTD Drug ID
DMIS7NT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetoacetyl-CoA thiolase (ACAT1) TTK3C21 THIL_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Acetoacetyl-CoA thiolase (ACAT1) DTT ACAT1 11.895 9.347 10.477 9.253
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Acetoacetyl-CoA thiolase (ACAT1) DTT ACAT1 4.99E-05 0.73 1.46
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8.