Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIZQW6)

Drug Name

LYSICAMINE Drug Info

Synonyms

Lysicamine; Oxonuciferine; 15444-20-9; CCRIS 3813; NSC 628003; BRN 1486372; UNII-6L30DD6R7O; CHEMBL510090; 6L30DD6R7O; CHEBI:70650; 1,2-Dimethoxy-7H-dibenzo(de,g)quinolin-7-one; NSC628003; 7H-Dibenzo(de,g)quinolin-7-one, 1,2-dimethoxy-; Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2-dimethoxy-; 7H-Dibenzo[de,g]quinolin-7-one, 1,2-dimethoxy-; 5-21-13-00382 (Beilstein Handbook Reference); (+)-ushinsunine-beta-N-oxide; SCHEMBL2046474; AC1L3V30; DTXSID00165628; MolPort-044-754-181; DPBMWJXWUINLQT-UHFFFAOYSA-N; BDBM50292452

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 122691
ChEBI ID: CHEBI:70650
CAS Number: CAS 15444-20-9
TTD Drug ID: DMIZQW6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acetylcholinesterase (AChE)	DTT	ACHE	1.678	1.926	1.766	5.252

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation. J Nat Prod. 2010 Oct 22;73(10):1632-5.