Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ4KQS)

• Drug Name: GW-406381 Drug Info
• Synonyms: GW 406381; GW406381; 8-(4-ethoxyphenyl)-7-(4-methylsulfonylphenyl)-1,2,9-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene

Indication

Disease Entry	ICD 11	Status	REF
Neuropathic pain	8E43.0	Discontinued in Phase 3	[1]
Osteoarthritis	FA00-FA05	Discontinued in Phase 3	[1]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 9832687
  CAS Number: CAS 221148-46-5
  TTD Drug ID: DMJ4KQS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Neuropathic pain
• ICD Disease Classification: 8E43.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 2 (COX-2)	DTT	PTGS2	2.08E-01	1.68E-03	0.03

References

• [1] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.