Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ6MPO)

Drug Name

(+/-)-2-Methyl-1-(1-phenylethyl)-1H-imidazole Drug Info

Synonyms

Efetozole; CHEMBL1269155; Efetozole [INN]; 2-methyl-1-(1-phenylethyl)-1H-imidazole; AC1L4LLD; (+/-)-2-Methyl-1-(1-phenylethyl)-1H-imidazole; SCHEMBL2109012; MolPort-020-890-666; CGP-22364A; BDBM50330055; 2-methyl-1-(1-phenylethyl)imidazole; AKOS013440375; 90408-21-2; (+-)-2-Methyl-1-(alpha-methylbenzyl)imidazole; (- )-2-Methyl-1-(alpha-methylbenzyl)imidazole.

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 208911
CAS Number: CAS 99500-54-6
TTD Drug ID: DMJ6MPO

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9.