Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJCQKA)

Drug Name
Sphingosine-1-phosphate Drug Info
Synonyms
Sphingosine 1-phosphate; sphingosine-1-phosphate; 26993-30-6; D-erythro-Sphingosine-1-phosphate; C18-Sphingosine 1-phosphate; Sphing-4-enine 1-phosphate; S1P; CHEBI:37550; D-erythro-sphingosine 1-phosphate; UNII-YVE187NJ1U; Sphingosine 1-phosphic acid; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate; Sphing-4-enine-1-phosphate; YVE187NJ1U; CHEMBL225155; DUYSYHSSBDVJSM-KRWOKUGFSA-N; 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydroge
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Phase 1 [1]
Cross-matching ID
PubChem CID
5283560
ChEBI ID
CHEBI:37550
CAS Number
CAS 26993-30-6
TTD Drug ID
DMJCQKA
VARIDT Drug ID
DR00118
INTEDE Drug ID
DR1811

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 1 (S1PR1) TT9JZCK S1PR1_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Protein spinster homolog 2 (SLC63A2) DT3Q1UO SPNS2_HUMAN Phase 1 [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Phase 1 [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Phase 1 [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Sphingosine kinase 1 (SPHK1) DELSNWC SPHK1_HUMAN Phase 1 [6]
Phospholipid phosphatase 1 (PLPP1) DE6WXTH PLPP1_HUMAN Phase 1 [7]
Sphingosine kinase 2 (SPHK2) DES1RUQ SPHK2_HUMAN Phase 1 [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sphingosine-1-phosphate receptor 1 (S1PR1) DTT S1PR1 6.829 6.89 6.853 5.959
P-glycoprotein 1 (ABCB1) DTP P-GP 7.009 6.988 7.442 8.135
Breast cancer resistance protein (ABCG2) DTP BCRP 6.732 7.513 6.326 9.277
Sphingosine kinase 2 (SPHK2) DME SPHK2 4.838 6.311 5.965 6.425
Sphingosine kinase 1 (SPHK1) DME SPHK1 6.441 6.18 5.508 5.845
Phospholipid phosphatase 1 (PLPP1) DME PLPP1 8.13 9.434 8.937 8.284
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Acne vulgaris
ICD Disease Classification ED80
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
P-glycoprotein 1 (ABCB1) DTP P-GP 7.23E-01 -8.20E-02 -3.22E-01
Breast cancer resistance protein (ABCG2) DTP BCRP 9.93E-01 -1.09E-01 -5.77E-01
Protein spinster homolog 2 (SLC63A2) DTP SPNS2 7.71E-01 1.32E-01 3.22E-01
Sphingosine kinase 2 (SPHK2) DME SPHK2 3.76E-01 -1.13E-01 -3.06E-01
Sphingosine kinase 1 (SPHK1) DME SPHK1 7.97E-01 -1.10E-01 -2.17E-01
Phospholipid phosphatase 1 (PLPP1) DME PLPP1 2.26E-01 -9.22E-02 -2.63E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 911).
2 Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2520-4.
3 The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC63A2)
4 Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem. 2010 Apr 2;285(14):10477-86.
5 Lipid dependence of ABC transporter localization and function. Chem Phys Lipids. 2009 Oct;161(2):57-64.
6 Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem. 2003 Nov 28;278(48):47408-15.
7 Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PLoS One. 2018 Jun 11;13(6):e0198063.